Fig. 1.

Comparison of nerve sheath tumor resistance loci, Nstr1 and Nstr2, to quantitative trait loci for variation in Nf1 expression levels. Top panels show previously identified Nstr2 (a) on chromosome 15 and Nstr1 (b) on chromosome 19 [28]. Bottom panels show interval mapping for levels of Nf1 expression (Affy probe 1452525_a_at) in the striatum (c) and the mid- and forebrain (d). Nstr1 and Nstr2 linkage is dependent on whether NPcis mutant progeny are generated from mutant mothers (red line, a and b) or mutant fathers (blue line, a and b) [28]. In the lower panels, the likelihood ratio statistic (LRS) is shown in blue, and the additive effect is shown in red. The horizontal dashed blue line indicates statistically significant linkage based on permutation testing (genome-wide P=0.05), and the horizontal dashed green line indicates statistically suggestive linkage based on permutation testing (genome-wide P=0.63). Yellow bars indicate the frequency of the LRS peak location using bootstrap resampling. Red vertical lines between the top and bottom panels indicate common markers used in the two mapping studies and were used to calibrate the results of the WebQTL analysis to the results of the tumor susceptibility mapping