Table 2.
Laminar analysis metrics of the distal tibia displayed per group: non-diabetic postmenopausal women with (Fx) and without (Co) history of fragility fractures and T2D postmenopausal women with (DMFx) and without history of fragility fractures (DM) after the onset of T2D
| Co (n=20) | Fx (n=20) | DM (n=19) | DMFx >(n=20) | Dm vs DMFx % relative difference | Dm vs DMFx p value |
|---|---|---|---|---|---|
| Total pore area (TPA) (mm2/mm2) | |||||
| Endosteal TPA 0.0647±0.03 | 0.0636±0.03 | 0.0630±0.03 | 0.0853±0.05 | +35.4 % | p=0.169 |
| Midcortical TPA 0.0374±0.05 | 0.0448±0.05 | 0.0180±0.01 | 0.0668±0.08 | +271.1 % | p=0.001 |
| Periosteal TPA 0.0149±0.02 | 0.0255±0.02 | 0.0112±0.01 | 0.0250±0.02 | +123.2 % | p=0.028 |
| Total pore number (TPN) (mm−2) | |||||
| Endosteal TPN 1.24±0.56 | 1.30±0.64 | 1.28±0.59 | 1.49±0.61 | +16.4 % | p=0.216 |
| Midcortical TPN 0.68±0.55 | 0.89±0.70 | 0.46±0.33 | 1.02±0.67 | +121.7 % | p=0.005 |
| Periosteal TPN 0.35±0.31 | 0.56±0.40 | 0.30±0.23 | 0.55±0.38 | +83.3 % | p=0.033 |
| Average pore area (APA) (mm2) | |||||
| Endosteal APA 0.0504±0.01 | 0.0487±0.01 | 0.0490±0.01 | 0.0563±0.01 | +14.9 % | p=0.136 |
| Midcortical APA 0.0451±0.03 | 0.0442±0.01 | 0.0390±0.01 | 0.0542±0.03 | +39.0 % | p=0.007 |
| Periosteal APA 0.0358±0.01 | 0.0403±0.01 | 0.0345±0.01 | 0.0408±0.01 | +18.3 % | p=0.043 |
Total pore area (TPA) (mm2/mm2), total pore number (TPN) (mm−2), and average pore area (APA) (mm2) were calculated for each layer. TPA and TPN were normalized by the area of each layer. All values are reported as the average across all slices. Data are expressed as unadjusted means±SD.
Significant p values are highlighted in bold