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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Biomaterials. 2019 Jan 7;197:345–367. doi: 10.1016/j.biomaterials.2019.01.011

Figure 2. Structure, properties and clinical applications of cyanoacrylate adhesives.

Figure 2.

(A) Preparation and anionic polymerization reaction (crosslinking) of cyanoacrylate monomers. Adapted from Scognamiglio et al. [61] with permission from Wiley, copyright 2016. (B) Cyanoacrylate glue applications techniques, (i) traditional technique: direct application of a drop of cyanoacrylate glue on a pre-dried ocular tissue, and (ii) patient eye treated with this technique; (iii) infant cannula technique: a small disc of a non-adhesive material is cut with a punch biopsy, an infant cannula (without needle) is used to pick up and hold the disc, a drop of glue is applied on the disc, and finally the glue is placed gently on the pre-dried ocular tissue, (iv) patient eye treated with this technique, (v) corneal tissue repaired with this technique. Adapted from Rana et al. [50] with permission from Elsevier, copyright 2013. (C) A polyglactin mesh glued with cyanoacrylate on a cadaver eye for strabismus surgery application, and effect of the polymerization time and surface area on the bonding strength of the mesh to the eye tissue. Adapted from Bona et al. [60] with permission from Elsevier, copyright 2014.