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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Ann Biomed Eng. 2019 Apr 12;47(7):1657–1674. doi: 10.1007/s10439-019-02256-7

Figure 2.

Figure 2

Overview schematic of current bloodstream infection diagnostic workflow. First, a 5 – 10 mL patient blood sample is cultured in 25 mL of nutrient rich media to determine if a pathogen is present13(1). Next, either culture-based or molecular methods are used to identify the pathogen(s) causing the infection (2). Above, we show a rapid (~2 h), molecular testing system for pathogen identification, the BioFire® FilmArray® Blood Culture Identification Panel (BCID). Reprinted under permission of the Creative Commons Attribution License93. Lastly, the organism’s susceptibility to antibiotics is determined (3). Here, we highlight the minimum inhibitory concentration (MIC) plate, which is a widely employed culture-based methodology.