Table 3:

Comparison matrix for primary literature reporting pathogen isolation from whole blood ^{2, 6, 10, 15, 18, 20, 21, 27, 28, 40, 42–44, 49, 50, 56, 63, 72, 82, 97, 111–114, 118, 119}.

AUTHOR, PUBLICATION YEAR	SEPARATION MECHANISM	MINIMUM CELL LOAD (CELLS/ML)*	CAPTURE EFFICIENCY*	PATHOGENS EVALUATED	SAMPLE FLOW RATE	ON-CHIP DETECTION?	SPECIES ID?	AST?
AI ET AL., 20032	Acoustophoresis	3 × 106	95.65% (purity)	E. coli	0.5 µL/min	●	●	●
ARAZ ET AL., 20036	Acoustophoresis	Not specified	Not specified	E. coli	n/a	●	●	●
BISCEGLIA ET AL., 201510	Dielectrophoresis	1 × 104	97% (E. coli)	E. coli, S. epidermis, C. albicans	10 – 20 µL/h	●	●	●
CAI ET AL., 201415	Dielectrophoresis	1 × 10^3	70.9–94.8%	E. coli	1µL/min	●	● (On-Chip PCR)	●
CHO ET AL., 200718	Immunomagnetic	1 × 105	93.40%	E. coli	12 min (Total analysis time)	●	● (Integrated in separation)	●
COOPER ET AL., 201420	Immunomagnetic	1 × 100–1	98%	C. albicans	10 mL/h	●	●	●
D’AMICO ET AL., 201721	Dielectrophoresis	1 × 103	78–79%	E. coli, S. aureus	10 µL/min	●	● (Off-Chip PCR)	●
DOW ET AL., 201827	Acoustophoresis	1.2 × 102	68% (P. aeruginosa)	E. coli, P. aeruginosa, S. aureus	50 µL/min	●	● (Off-Chip Luminescence Assay)	●
FARIDI ET AL., 201728	Inertial	1 × 106	76%	E. coli	30 – 60 µL/h	●	●	●
HOU ET AL., 201540	Inertial	1 × 101	>10%	E. coli, P. aeruginosa, K. pneumoniae, S. aureus, E. faecalis	50 µL/min	●	● (Off-Chip PCR)	●
HUANG ET AL., 200342	Dielectrophoresis	4.6 × 103	89%	E. coli, B. cereus, L. monocytogenes	n/a	●	● (Off-Chip PCR)	●
HWANG ET AL., 200843	Adhesion	1 × 107	40%	E. coli	200 µL/min	●	● (Off-Chip PCR)	●
HWANG ET AL., 201144	Adhesion	1 × 104	40%	E. coli	200 µL/min	●	● (Off-Chip PCR)	●
KANG ET AL., 201449	Nanodroplets	1 × 100	77%	E. coli	0.5 – 3 µL/min	●	● (Nature of Target Complex)	●
KANG ET AL., 201450	Immunomagnetic	1 × 104	>90%	S. aureus, E. coli, C. albicans	10 mL/h	●	●	●
KUCXSENSKI ET AL., 201156	Dielectrophoresis	1 × 106	30%	E. coli	35 µL/h	●	●	●
LEE ET AL., 201363	Immunomagnetic	5 × 106	>95%	E. coli	60 mL/h	●	●	●
MACH ET AL., 201072	Inertial	1 × 108	>80%	E. coli	200 µL/min	●	●	●
OHLSSON ET AL., 201682	Acoustophoresis	1 × 103	10%	P. putida	80 µL/min	●	● (Off-Chip PCR)	●
RAUB ET AL., 201497	Size-exclusion	2.2 × 106	30%	E. coli	~100 µL/min	●	●	●
WANG ET AL., 2012111	Immuno-affinity	5 × 101	70.7%	E. coli	2 µL/min	●	● (Integrated in separation)	●
WEI-HOU ET AL., 2012112	Inertial	1 × 106	80–90%	E. coli, S. cerevisiae	15 µL/min	●	●	●
WU ET AL., 2009113	Inertial	1 × 107.2	62%	E. coli	2 – 18 µL/min	●	●	●
XIA ET AL., 2006114	Immunomagnetic	5 × 106	78%	E. coli	25 µL/h	●	● (Integrated in separation)	●
YUNG ET AL., 2009118	Immunomagnetic	1 × 106	80%	C. albicans	20 mL/h	●	● (Integrated in separation)	●
ZELENIN ET AL., 2014119	Targeted cell lysis	1 × 107	100%	E. coli, M. luteus	48 µL/min	●	●	●

^*Data for lowest reported cell concentration evaluated with statistically different results from control. Pathogens evaluated include only those where separation from whole blood was reported. ID = identification; AST = antibiotic susceptibility testing; ● = no; ● = yes.