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. Author manuscript; available in PMC: 2019 Aug 8.
Published in final edited form as: Xenotransplantation. 2017 Sep 22;24(6):10.1111/xen.12339. doi: 10.1111/xen.12339

Table 1:

Experimental groups by liver genotype and drug regimen used

Group Experiment Duration (min) Liver Genotype Perfusion Blood
Treatment
Anhepatic controls C1 480* Anhepatic circuit Famotidine, BIA
C2 900* Anhepatic circuit Famotidine, BIA, αGPIb
Allogenic controls
(porcine blood) 		A1 480* GalTKO.hCD46 Famotidine, BIA, αGPIb
A2 480* GalTKO.hCD46 Famotidine, BIA, αGPIb
A3 660* GalTKO.hCD46 Famotidine, BIA, αGPIb
Group 1A 816−11 115 GalTKO.hCD46 Famotidine, BIA, αGPIb
850−12 597 GalTKO.hCD46 Famotidine, BIA, αGPIb
850−06 202 GalTKO.hCD46 Famotidine, BIA, αGPIb
Group 1B 850−04 208 GalTKO.hCD46
851−05 600 GalTKO.hCD46
857−03 195 GalTKO.hCD46
857−04 600 GalTKO.hCD46
Group 2A 727−01 125 GalTKO.hCD46.
Neu5GcKO		 Famotidine, BIA, αGPIb
726−04 480 GalTKO.hCD46.
Neu5GcKO		 Famotidine, BIA, αGPIb
Group 2B 720−01 160 GalTKO.hCD46.
Neu5GcKO
724−02 240 GalTKO.hCD46.
Neu5GcKO
724−01 480 GalTKO.hCD46.
Neu5GcKO
*

Experiments were electively terminated