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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Genet Epidemiol. 2019 May 18;43(6):657–674. doi: 10.1002/gepi.22211

Figure 5.

Figure 5.

Mediation analyses to assess whether plasma glycine mediates the relationships between imputed CPS1 expression, BMI, WHR, IL-6, and HOMA-IR. A. Total effect of CPS1 on BMI. B. Direct and indirect effects of CPS1 on BMI. C. Total effect of CPS1 on WHR. D. Direct and indirect effects of CPS1 on WHR. E. Total effect of CPS1 on IL-6. F. Direct and indirect effects of CPS1 on IL-6. F. Total effect of CPS1 on HOMA-IR. G. Direct and indirect effects of CPS1 on HOMA-IR. All models adjusted for age and sex; models including CPS1 additionally adjusted for the first four PCs; models that included glycine additionally adjusted for cholesterol lowering medication use and sample storage time.