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. Author manuscript; available in PMC: 2020 Aug 7.
Published in final edited form as: J Am Chem Soc. 2019 Jul 29;141(31):12388–12396. doi: 10.1021/jacs.9b05850

Scheme 3.

Scheme 3.

Systematic Control of Degree and Sense of Asymmetric Induction in Intramolecular Radical 1,5-C−H Amination of Sulfamoyl Azide by [Co(HuPhyrin)]a,b,c,d

a Reactions were performed on a 0.10 mmol scale of sulfamoyl azide 1a using 2 mol % of [Co(HuPhyrin)] in 1.0 mL of methyl tert-butyl ether (MTBE) at 40 °C; [1a] = 0.10 M. b Yields in the Supporting Information. c Absolute configuration determined by X-ray crystal structural analysis. d Enantiomeric ratios (er) determined by chiral HPLC analysis.