(A) Plasma eNAMPT levels of female and male mice at 6 and 18 months of age (n=5).
(B) Plasma eNAMPT concentrations of female and male mice at 6 and 18 months of age over a 24-hr period (n=5 per time point per age). The differences between plasma eNAMPT levels at 6 and 18 months of age were assessed by two-way repeated measures ANOVA, and the age effects were significant in both males and females (p<0.05).
(C) Plasma eNAMPT levels of mice and humans across different age groups (n=9 for mice; n=13 for humans).
(D) Relationship of plasma eNAMPT levels and the remaining lifespans of individual mice (n=8). eNAMPT levels were measured at 26-28 months of age.