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. Author manuscript; available in PMC: 2020 Aug 6.
Published in final edited form as: Cell Metab. 2019 Jun 13;30(2):329–342.e5. doi: 10.1016/j.cmet.2019.05.015

Figure 5. Female ANKI mice exhibit significant extension of median lifespan and delay in aging.

Figure 5.

(A) Kaplan-Meier curves of female and male ANKI mice (females, control 39, ANKI 40; males, control 39, ANKI 39).

(B) Lifespan parameters of control and ANKI mice. Mean and maximal lifespans of the oldest 10% and 20% of each cohort are shown as mean values ± SEM. The differences in survival curves and mean lifespans were assessed by Gehan-Breslow-Wilcoxon test and Student’s t test, respectively.

(C) Age-associated mortality rates of control and ANKI female and male mice.

(D) Identified causes of death in aged control and ANKI mice (n=37). Sarcoma subtypes includes histio-, hemangio-, lipo-, and fibrosarcoma, and carcinoma subtypes includes hepatocellular, bronchiolo-alveolar, and cholangiocarcinoma.