Figure 4:

Loss of CD11c⁺ APC SGK1 prevents salt-sensitive hypertension induced renal immune cell infiltration and fibrosis. Representative images of (A) renal CD3⁺ T lymphocytes (original magnification 200X) and (B) summary data from SGK1^fl/fl controls and SGK1^CD11cKO mice after L-NAME/high-salt feeding. Masson’s Trichrome staining of (A) renal perivascular fibrosis (original magnification 600X) and (B) semiquantitative scoring in SGK1^fl/fl and SGK1^CD11cKO mice after L-NAME/high-salt feeding. *P<0.05; ***P<0.001; student’s t-test; n=4-6 per group. All data are expressed as a mean ± SEM.