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. 2019 Aug;12(3):167–183. doi: 10.2174/1874467212666190304121131

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© 2019 Bentham Science Publishers

This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (12) — Non-canonical planar cell polarity is p300-dependent. To investigate the effects of differential p300 versus CBP coactivator usage on planar cell polarity (PCP), we examined cochlear hair cell development during mouse embryonic development ex vivo. E14.5 mouse cochleae were placed into culture and treated for 6 days, with indirect p300/Iý-catenin antagonist IQ-1 or direct CBP/Iý-catenin antagonist ICG-001 versus vehicle control. Whereas inhibition of CBP/Iý-catenin interaction did not have any deleterious effects on cochlear development and stereocilia orientation, inhibition of the p300/Iý-catenin interaction disrupted PCP and cochlear hair cell orientation. ICG-001, in a dose dependent fashion, reversed the deleterious effects of IQ-1 on PCP. OHC, outer hair cell; IHC, inner hair cell.