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. 2019 Aug;12(3):167–183. doi: 10.2174/1874467212666190304121131

Fig. (2).

Fig. (2)

ICG-001 blocks the association of CBP with the c-myc promoter and concomitantly increases the level of p300 associated with the c-myc promoter. To evaluate coactivator usage at the endogenous c-myc promoter, chromatin immunoprecipitation (ChIP) analysis was performed on SW480 cells treated with either ICG-001 (25 AæM) or control DMSO. The c-myc promoter is occupied by both coactivators CBP and p300 in control DMSO treated cells. However, treatment with ICG-001 completely and selectively blocks the association of CBP with the c-myc promoter and concomitantly increases the level of p300 associated with this promoter. D, DMSO (control) treatment. T, treatment with ICG-001.