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. 2019 Jul 10;7(8):e846. doi: 10.1002/mgg3.846

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© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Jointed effects of the vitamin K epoxide reductase complex subunit 1 (VKORC1) and Chr.9p21.3 interactions with environmental factors on stroke risk. Abbreviations: Ref, reference group. The odds ratio (ORs) and p values were calculated by the logistic regression analysis after adjustment for age, gender, and conventional vascular risk factors, and correction for multiple comparisons. (a) Joint effects of the VKORC1 rs2359612 and Chr.9p21.3 rs10757274 with hypertension on stroke risk, and the reference group was defined as subjects without hypertension and carrying wild‐type genotypes of rs2359612TT and rs10757274AA; (b) Joint effects of the VKORC1 rs2359612 and Chr.9p21.3 rs10757274 with physical inactivity on stroke risk, and the reference group was defined as subjects with regular exercise and carrying wild‐type genotypes of rs2359612TT and rs10757274AA