Table 3.
Association between biochemical characteristics and SNPs of genes in STAT3 signaling pathway in HCV‐infected persons
| Marker | rs1524107 (IL6) | rs2069837 (IL6) | ||||||
|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | P‐value | AA | AG | GG | P‐value | |
| GGT | 46.92 ± 6.22 | 61.77 ± 6.14 | 54.28 ± 4.11 | 0.410 | 56.81 ± 4.07 | 58.35 ± 6.06 | 36.38 ± 9.21 | 0.512 |
| ALT | 70.85 ± 13.48 | 53.98 ± 3.79 | 75.89 ± 16.23 | 0.525 | 74.53 ± 13.99 | 54.75 ± 4.45 | 46.46 ± 11.58 | 0.559 |
| AST | 63.69 ± 9.24 | 54.56 ± 2.85 | 75.58 ± 17.84 | 0.696 | 73.74 ± 15.34 | 55.07 ± 3.31 | 45.69 ± 6.31 | 0.639 |
| ALB | 45.39 ± 0.81 | 44.37 ± 0.44 | 45.22 ± 0.24 | 0.156 | 45.04 ± 0.25 | 44.57 ± 0.45 | 45.74 ± 1.36 | 0.484 |
| TBIL | 14.10 ± 1.05 | 26.94 ± 6.79 | 15.04 ± 0.44 | 0.080 | 15.16 ± 0.43 | 28.68 ± 8.02 | 14.93 ± 1.55 | 0.051 |
| HDL‐C | 1.19 ± 0.08 | 1.24 ± 0.04 | 1.26 ± 0.03 | 0.770 | 1.25 ± 0.03 | 1.26 ± 0.04 | 1.16 ± 0.12 | 0.758 |
| HCV RNA | 4.90 ± 0.23 | 4.79 ± 0.10 | 4.76 ± 0.08 | 0.846 | 4.81 ± 0.08 | 4.74 ± 0.10 | 4.28 ± 0.51 | 0.461 |
| Marker | rs2069852 (IL6) | rs4845617 (IL6R) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P‐value | AA | AG | GG | P‐value | |
| GGT | 56.06 ± 4.74 | 57.02 ± 5.23 | 57.48 ± 9.47 | 0.986 | 57.69 ± 8.07 | 57.77 ± 4.65 | 54.22 ± 5.51 | 0.884 |
| ALT | 80.63 ± 19.15 | 52.95 ± 3.56 | 63.85 ± 8.79 | 0.368 | 58.93 ± 4.72 | 77.79 ± 19.42 | 57.77 ± 5.24 | 0.570 |
| AST | 81.91 ± 21.09 | 51.87 ± 2.53 | 58.98 ± 6.10 | 0.358 | 57.75 ± 3.33 | 76.87 ± 21.40 | 58.58 ± 4.09 | 0.650 |
| ALB | 45.30 ± 0.26 | 44.65 ± 0.38 | 44.30 ± 0.75 | 0.232 | 44.92 ± 0.46 | 44.66 ± 0.33 | 45.28 ± 0.38 | 0.472 |
| TBIL | 15.19 ± 0.48 | 24.43 ± 6.08 | 19.39 ± 5.67 | 0.250 | 16.79 ± 0.82 | 21.29 ± 4.63 | 18.70 ± 4.59 | 0.783 |
| HDL‐C | 1.28 ± 0.04 | 1.25 ± 0.04 | 1.18 ± 0.06 | 0.416 | 1.28 ± 0.05 | 1.30 ± 0.04 | 1.17 ± 0.04 | 0.045 |
| HCV | 4.77 ± 0.09 | 4.83 ± 0.10 | 4.63 ± 0.18 | 0.588 | 4.71 ± 0.11 | 4.90 ± 0.10 | 4.66 ± 0.11 | 0.208 |
| Marker | rs4075015 (IL6R) | rs7553796 (IL6R) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AT | TT | P‐value | AA | AC | CC | P‐value | |
| GGT | 58.70 ± 7.10 | 53.80 ± 4.48 | 58.49 ± 5.99 | 0.777 | 44.97 ± 7.11 | 56.41 ± 4.19 | 62.45 ± 6.53 | 0.200 |
| ALT | 57.77 ± 6.26 | 58.12 ± 4.32 | 82.04 ± 23.12 | 0.445 | 46.11 ± 4.90 | 62.07 ± 4.32 | 84.40 ± 25.23 | 0.322 |
| AST | 59.70 ± 5.50 | 53.31 ± 2.52 | 84.94 ± 25.58 | 0.348 | 48.70 ± 3.38 | 59.15 ± 3.24 | 85.92 ± 27.92 | 0.347 |
| ALB | 45.01 ± 0.50 | 45.19 ± 0.33 | 44.56 ± 0.37 | 0.435 | 45.06 ± 0.51 | 45.05 ± 0.33 | 44.65 ± 0.36 | 0.681 |
| TBIL | 14.30 ± 0.84 | 18.98 ± 3.63 | 22.79 ± 5.51 | 0.480 | 22.12 ± 8.66 | 19.66 ± 4.24 | 17.97 ± 2.03 | 0.863 |
| HDL‐C | 1.18 ± 0.05 | 1.25 ± 0.04 | 1.29 ± 0.04 | 0.266 | 1.17 ± 0.05 | 1.25 ± 0.03 | 1.30 ± 0.05 | 0.215 |
| HCV | 4.65 ± 0.12 | 4.90 ± 0.10 | 4.73 ± 0.10 | 0.259 | 4.66 ± 0.15 | 4.85 ± 0.09 | 4.72 ± 0.10 | 0.456 |
| Marker | rs1053023 (STAT3) | rs1053004 (STAT3) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P‐value | CC | CT | TT | P‐value | |
| GGT | 47.09 ± 3.89 | 64.14 ± 5.36 | 64.88 ± 13.53 | 0.034 | 64.81 ± 12.61 | 61.69 ± 5.15 | 48.90 ± 4.16 | 0.132 |
| ALT | 54.16 ± 3.17 | 61.68 ± 4.00 | 63.71 ± 11.63 | 0.345 | 59.64 ± 10.28 | 60.63 ± 4.03 | 55.75 ± 3.73 | 0.683 |
| AST | 57.38 ± 3.42 | 56.52 ± 2.40 | 58.39 ± 7.54 | 0.960 | 56.94 ± 6.69 | 57.89 ± 2.86 | 56.10 ± 3.06 | 0.913 |
| ALB | 45.31 ± 0.29 | 44.64 ± 0.36 | 44.34 ± 0.76 | 0.259 | 44.22 ± 0.67 | 44.66 ± 0.36 | 45.36 ± 0.28 | 0.190 |
| TBIL | 19.18 ± 4.55 | 17.14 ± 1.59 | 34.74 ± 17.80 | 0.201 | 31.60 ± 15.42 | 17.11 ± 1.54 | 19.51 ± 4.83 | 0.293 |
| HDL‐C | 1.28 ± 0.03 | 1.24 ± 0.04 | 1.19 ± 0.11 | 0.581 | 1.18 ± 0.09 | 1.26 ± 0.04 | 1.26 ± 0.04 | 0.597 |
| HCV | 4.79 ± 0.10 | 4.74 ± 0.09 | 4.93 ± 0.20 | 0.703 | 4.90 ± 0.20 | 4.76 ± 0.09 | 4.77 ± 0.10 | 0.821 |
| Marker | rs4796793 (STAT3) | rs3787349 (HNF4A) | ||||||
|---|---|---|---|---|---|---|---|---|
| CC | CG | GG | P‐value | AA | AC | CC | P‐value | |
| GGT | 48.86 ± 4.00 | 59.78 ± 5.25 | 71.28 ± 11.45 | 0.087 | 34.25 ± 5.98 | 54.53 ± 4.71 | 59.60 ± 4.73 | 0.286 |
| ALT | 55.58 ± 3.97 | 58.87 ± 3.91 | 67.79 ± 9.20 | 0.414 | 49.25 ± 9.07 | 81.99 ± 23.29 | 58.76 ± 3.67 | 0.442 |
| AST | 57.66 ± 3.67 | 55.01 ± 2.36 | 64.05 ± 6.11 | 0.393 | 52.31 ± 6.71 | 84.27 ± 25.79 | 56.27 ± 2.45 | 0.389 |
| ALB | 45.25 ± 0.29 | 44.81 ± 0.34 | 44.11 ± 0.76 | 0.287 | 45.12 ± 0.60 | 44.86 ± 0.38 | 44.93 ± 0.28 | 0.968 |
| TBIL | 14.54 ± 0.47 | 20.78 ± 4.37 | 31.88 ± 13.37 | 0.130 | 14.23 ± 1.04 | 15.74 ± 0.68 | 14.75 ± 0.43 | 0.372 |
| HDL‐C | 1.30 ± 0.04 | 1.21 ± 0.03 | 1.27 ± 0.09 | 0.246 | 1.26 ± 0.15 | 1.23 ± 0.04 | 1.27 ± 0.03 | 0.829 |
| HCV | 4.82 ± 0.10 | 4.74 ± 0.09 | 4.81 ± 0.19 | 0.817 | 4.99 ± 0.35 | 4.89 ± 0.10 | 4.68 ± 0.08 | 0.204 |
| Marker | rs3212172 (HNF4A) | rs1800963 (HNF4A) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P‐value | AA | AC | CC | P‐value | |
| GGT | 58.81 ± 4.83 | 52.47 ± 4.52 | 63.90 ± 14.39 | 0.540 | 44.57 ± 7.82 | 59.40 ± 4.82 | 55.74 ± 5.08 | 0.498 |
| ALT | 57.40 ± 3.31 | 78.82 ± 22.19 | 74.10 ± 14.94 | 0.523 | 51.77 ± 8.36 | 77.88 ± 18.93 | 58.70 ± 3.98 | 0.539 |
| AST | 58.80 ± 2.79 | 77.58 ± 24.47 | 65.10 ± 8.45 | 0.669 | 48.93 ± 4.32 | 78.41 ± 20.85 | 57.66 ± 3.01 | 0.534 |
| ALB | 44.99 ± 0.25 | 44.88 ± 0.40 | 44.50 ± 0.93 | 0.846 | 45.01 ± 0.92 | 44.91 ± 0.31 | 44.90 ± 0.33 | 0.992 |
| TBIL | 21.43 ± 4.74 | 17.73 ± 1.91 | 15.19 ± 1.11 | 0.712 | 14.11 ± 1.00 | 20.24 ± 4.27 | 19.58 ± 3.61 | 0.833 |
| HDL‐C | 1.29 ± 0.03 | 1.22 ± 0.04 | 1.18 ± 0.07 | 0.325 | 1.21 ± 0.08 | 1.26 ± 0.04 | 1.25 ± 0.04 | 0.866 |
| HCV | 4.71 ± 0.08 | 4.90 ± 0.10 | 4.64 ± 0.23 | 0.279 | 4.52 ± 0.27 | 4.85 ± 0.09 | 4.74 ± 0.09 | 0.387 |
| Marker | rs6073435 (HNF4A) | rs1169309 (HNF1A) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AT | TT | P‐value | GG | GT | TT | P‐value | |
| GGT | 56.17 ± 4.92 | 58.03 ± 5.07 | 51.51 ± 7.61 | 0.845 | 51.21 ± 4.59 | 64.35 ± 5.47 | 46.12 ± 5.51 | 0.052 |
| ALT | 80.98 ± 21.92 | 58.41 ± 3.76 | 54.77 ± 8.07 | 0.461 | 62.81 ± 6.05 | 76.69 ± 17.86 | 52.07 ± 4.63 | 0.541 |
| AST | 80.50 ± 24.14 | 58.16 ± 3.09 | 53.67 ± 5.39 | 0.522 | 58.67 ± 3.95 | 77.88 ± 19.70 | 52.33 ± 3.48 | 0.528 |
| ALB | 45.14 ± 0.29 | 44.80 ± 0.35 | 44.49 ± 0.74 | 0.631 | 44.66 ± 0.49 | 44.89 ± 0.31 | 45.25 ± 0.39 | 0.634 |
| TBIL | 23.71 ± 6.06 | 16.74 ± 1.48 | 15.61 ± 2.49 | 0.396 | 21.57 ± 5.51 | 16.40 ± 1.46 | 23.72 ± 8.67 | 0.473 |
| HDL‐C | 1.26 ± 0.04 | 1.23 ± 0.03 | 1.33 ± 0.09 | 0.523 | 1.24 ± 0.05 | 1.26 ± 0.03 | 1.25 ± 0.05 | 0.945 |
| HCV | 4.82 ± 0.09 | 4.78 ± 0.09 | 4.54 ± 0.22 | 0.501 | 4.73 ± 0.11 | 4.81 ± 0.09 | 4.76 ± 0.13 | 0.878 |
| Marker | rs11065390 (HNF1A) | rs1885301 (ABCC2) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P‐value | AA | AG | GG | P‐value | |
| GGT | 47.00 ± 6.55 | 60.44 ± 5.44 | 54.89 ± 4.53 | 0.533 | 69.54 ± 17.59 | 62.34 ± 6.03 | 52.92 ± 3.99 | 0.313 |
| ALT | 45.65 ± 6.27 | 63.64 ± 4.58 | 72.77 ± 17.02 | 0.735 | 82.31 ± 21.61 | 91.36 ± 26.62 | 53.72 ± 3.13 | 0.152 |
| AST | 51.00 ± 5.67 | 59.35 ± 3.04 | 74.59 ± 18.78 | 0.702 | 64.54 ± 9.45 | 90.33 ± 29.41 | 54.51 ± 2.48 | 0.245 |
| ALB | 43.80 ± 0.92 | 44.88 ± 0.34 | 45.08 ± 0.30 | 0.374 | 47.94 ± 0.77 | 44.64 ± 0.35 | 44.90 ± 0.29 | 0.034 |
| TBIL | 36.51 ± 21.89 | 16.53 ± 1.76 | 19.62 ± 3.86 | 0.185 | 14.65 ± 1.44 | 25.79 ± 7.38 | 16.38 ± 1.21 | 0.224 |
| HDL‐C | 1.11 ± 0.08 | 1.27 ± 0.04 | 1.26 ± 0.03 | 0.312 | 1.23 ± 0.16 | 1.22 ± 0.04 | 1.27 ± 0.03 | 0.556 |
| HCV | 4.54 ± 0.31 | 4.93 ± 0.09 | 4.68 ± 0.08 | 0.091 | 4.48 ± 0.26 | 4.90 ± 0.10 | 4.73 ± 0.08 | 0.274 |
| Marker | rs7910642 (ABCC2) | rs2804402 (ABCC2) | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | P‐value | AA | AG | GG | P‐value | |
| GGT | 54.40 ± 9.42 | 57.93 ± 5.19 | 55.70 ± 4.64 | 0.926 | 52.80 ± 3.95 | 62.81 ± 6.16 | 69.54 ± 17.59 | 0.282 |
| ALT | 60.78 ± 8.95 | 56.92 ± 3.96 | 80.43 ± 21.09 | 0.468 | 54.12 ± 3.11 | 91.45 ± 27.23 | 82.31 ± 21.61 | 0.160 |
| AST | 58.43 ± 5.93 | 55.89 ± 3.12 | 81.12 ± 23.27 | 0.472 | 54.65 ± 2.46 | 90.90 ± 30.09 | 64.54 ± 9.45 | 0.241 |
| ALB | 45.44 ± 0.59 | 44.68 ± 0.32 | 45.04 ± 0.35 | 0.541 | 44.92 ± 0.29 | 44.58 ± 0.35 | 47.94 ± 0.77 | 0.030 |
| TBIL | 14.99 ± 0.76 | 19.29 ± 4.27 | 20.76 ± 3.83 | 0.816 | 19.54 ± 3.36 | 19.84 ± 4.46 | 14.65 ± 1.44 | 0.941 |
| HDL‐C | 1.32 ± 0.07 | 1.25 ± 0.03 | 1.25 ± 0.04 | 0.639 | 1.28 ± 0.03 | 1.21 ± 0.04 | 1.22 ± 0.16 | 0.495 |
| HCV | 4.63 ± 0.20 | 4.82 ± 0.09 | 4.76 ± 0.09 | 0.653 | 4.73 ± 0.08 | 4.91 ± 0.10 | 4.48 ± 0.26 | 0.239 |
| Marker | rs717620 (ABCC2) | |||
|---|---|---|---|---|
| AA | AG | GG | P‐value | |
| GGT | 66.50 ± 18.84 | 64.18 ± 6.52 | 52.67 ± 3.83 | 0.240 |
| ALT | 83.33 ± 23.47 | 95.13 ± 29.01 | 53.62 ± 3.00 | 0.111 |
| AST | 65.58 ± 10.21 | 94.13 ± 32.07 | 54.25 ± 2.38 | 0.188 |
| ALB | 47.52 ± 0.70 | 44.62 ± 0.37 | 44.93 ± 0.28 | 0.090 |
| TBIL | 14.95 ± 1.53 | 20.16 ± 4.75 | 19.37 ± 3.24 | 0.944 |
| HDL‐C | 1.22 ± 0.18 | 1.21 ± 0.04 | 1.28 ± 0.03 | 0.458 |
| HCV | 4.42 ± 0.28 | 4.89 ± 0.11 | 4.74 ± 0.08 | 0.278 |
| Marker | rs2069840 (IL6) | rs12090237 (IL6R) | rs4845374 (IL6R) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CC | CG | P‐value | AA/AG | GG | P‐value | AA/AT | TT | P‐value | |
| GGT | 56.03 ± 3.44 | 61.24 ± 10.94 | 0.614 | 57.84 ± 9.97 | 56.52 ± 3.47 | 0.914 | 62.07 ± 6.26 | 54.13 ± 3.84 | 0.262 |
| ALT | 67.44 ± 10.29 | 66.00 ± 9.57 | 0.960 | 174.0 ± 111.9 | 58.16 ± 2.81 | 0.0006 | 84.64 ± 28.25 | 59.30 ± 3.37 | 0.200 |
| AST | 67.45 ± 11.25 | 62.16 ± 6.56 | 0.867 | 183.9 ± 124.6 | 56.84 ± 2.07 | 0.0006 | 87.15 ± 31.33 | 57.52 ± 2.39 | 0.169 |
| ALB | 45.07 ± 0.23 | 43.70 ± 0.75 | 0.048 | 44.43 ± 0.92 | 44.95 ± 0.23 | 0.522 | 44.84 ± 0.38 | 44.95 ± 0.27 | 0.818 |
| TBIL | 20.15 ± 2.92 | 14.26 ± 1.23 | 0.470 | 18.41 ± 2.21 | 19.57 ± 2.81 | 0.905 | 24.02 ± 6.75 | 17.39 ± 2.17 | 0.235 |
| HDL‐C | 1.27 ± 0.03 | 1.16 ± 0.06 | 0.192 | 1.32 ± 0.11 | 1.25 ± 0.03 | 0.463 | 1.23 ± 0.04 | 1.27 ± 0.03 | 0.505 |
| HCV | 4.74 ± 0.06 | 5.02 ± 0.18 | 0.136 | 5.11 ± 0.24 | 4.75 ± 0.06 | 0.138 | 4.73 ± 0.12 | 4.80 ± 0.07 | 0.572 |
| Marker | rs4509570 (IL6R) | rs2273697 (ABCC2) | ||||
|---|---|---|---|---|---|---|
| CC | CG/GG | P‐value | AA/AG | GG | P‐value | |
| GGT | 58.57 ± 3.95 | 50.90 ± 5.72 | 0.310 | 55.40 ± 7.64 | 56.87 ± 3.64 | 0.868 |
| ALT | 71.42 ± 12.20 | 55.08 ± 4.52 | 0.439 | 107.6 ± 53.73 | 59.32 ± 2.91 | 0.051 |
| AST | 70.83 ± 13.34 | 55.11 ± 3.34 | 0.494 | 113.7 ± 59.64 | 57.59 ± 2.14 | 0.037 |
| ALB | 45.03 ± 0.24 | 44.56 ± 0.51 | 0.348 | 45.14 ± 0.49 | 44.87 ± 0.25 | 0.648 |
| TBIL | 18.63 ± 2.86 | 21.97 ± 5.80 | 0.576 | 16.99 ± 1.71 | 19.97 ± 3.09 | 0.670 |
| HDL‐C | 1.27 ± 0.03 | 1.20 ± 0.04 | 0.230 | 1.35 ± 0.07 | 1.24 ± 0.03 | 0.088 |
| HCV | 4.78 ± 0.07 | 4.78 ± 0.12 | 0.990 | 4.83 ± 0.15 | 4.77 ± 0.07 | 0.717 |
All biochemical characteristic were Mean ± SE.
Abbreviations: ALB, albumin; ALT (or GPT), glutamic‐pyruvic transaminase; AST (or GOT), aspartate amino‐transferase; GGT, Glutamyl transpeptidase; HDL‐C, high‐density lipoprotein cholesterol; TBIL, total bilirubin