Fig. 6.
The Mixed subtype has biology associated with Wnt/stromal signaling. a Pathway enrichment of significantly different proteins (±1.5 fold-change and Padj < 0.05 compared to the rest of the cohort). There were no significantly elevated pathways in Mixed, but several pathways were decreased including immune and oxidation-reduction pathways. b Principal component analysis of the three subtypes reveal distinct clustering of Inflamed to the left, Redox on the right, and Mixed interspersed throughout. c Lollipop plot of APC alterations in the cohort with PFAM domain annotation (https://pfam.xfam.org/) extracted from cBioPortal (http://www.cbioportal.org). Mutations with black lines were nonsynonymous and red lines were truncating. Inflamed had no APC mutations