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. 2019 Aug 8;10(8):599. doi: 10.1038/s41419-019-1835-3

Fig. 4. LINC00511 accelerates the G1/S transition, in part, by regulating CDKN1B expression.

Fig. 4

a Flow cytometry (cell cycle distribution) analysis of the proportion of UACC-812 and MDA-MB-231 cells in the G0/G1, S and G2/M phases following the knockdown of LINC00511 expression. b Flow cytometry (cell cycle distribution) analysis of the proportion of MDA-MB-231 cells in the G0/G1, S and G2/M phases following the overexpression of LINC00511 expression. c Western blot analysis of the key cell cycle-related proteins (CCNE1, CCND1, CDK4, CDK2 and CDKN1B) of UACC-812 and MDA-MB-231 cells following the knockdown of LINC00511 expression. d Western blot analysis of the key cell cycle-related proteins (CCNE1, CCND1, CDK4, CDK2 and CDKN1B) of MDA-MB-231 cells following the overexpression of LINC00511 expression. e qRT-PCR analysis of CDKI mRNAs (the INK4 and Cip/Kip families) of UACC-812 and MDA-MB-231 cells following the knockdown of LINC00511 expression. f Scatter diagram analysis of the correlation between LINC00511 and CDKN1B expression obtained from the CCLE database. g Scatter diagram analysis of the correlation between LINC00511 and CDKN1B expression generated from the TCGA database. h Scatter diagram analysis of the correlation between LINC00511 and CDKN1B expression in 70 breast cancer tissues in our cohort. Data are shown as the mean ± SD. Student’s t test was used for the statistical analysis: *p < 0.05; **p < 0.01; ***p < 0.001. Data represent three independent experiments