Fig. 6. Knockdown of LINC00511 expression represses tumour growth in vivo.

a qRT-PCR analysis of the knockdown efficiency of LINC00511 expression in luciferase-labelled MDA-MB-231 cells. b Representative images of nude mice bearing tumours from the shcontrol and shLINC00511 cohorts. c The growth curves of tumour volumes calculated every 3 days after injection in the shcontrol and shLINC00511 cohorts. d Representative images of tumours from the shcontrol and shLINC00511 cohorts. e Representative bioluminescent images of nude mice bearing tumours of luciferase-labelled MDA-MB-231 cells from the shcontrol and shLINC00511 cohorts. Image capture occurred during the 1st, 3rd and 5th weeks. f Scatter diagram depiction of the final tumour weights in shcontrol and shLINC00511 cohorts. g Representative images of haematoxylin and eosin (H&E) staining and Ki-67 and CDKN1B immunostaining of tumours from the shcontrol and shLINC00511 cohorts. Data are shown as the mean ± SD. Student’s t test was used for the statistical analysis: *p < 0.05; **p < 0.01; ***p < 0.001. Data represent three independent experiments