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. 2019 Aug 8;10:3569. doi: 10.1038/s41467-019-11396-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Preferential TCR usage in blister cells and PBMC from patients with SJS/TEN. The PBMC and blister cells were isolated from patients with SJS/TEN caused by carbamazepine (CBZ; n = 18), oxcarbazepine (OXC; n = 3), lamotrigine (LTG; n = 4), phenytoin (PHT; n = 6), or allopurinol (ALP; n = 10). The expression profiles of TCR repertoire in the samples were analyzed by next-generation sequencing. a Heatmaps display the expression values of the TRBV genes from each sample, which were normalized to the mean values of the corresponding gene of the healthy donors’ PBMC (n = 44), respectively. The definition of TRBV and TRBJ was based on the IMGT (ImMunoGeneTics) database. b Principal component analysis (PCA) of TRBV gene usage across samples from patients (n = 41) with SJS/TEN caused by different drugs, and healthy donors (n = 44)