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. 2019 Aug 8;2:303. doi: 10.1038/s42003-019-0550-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Co-treatment with iEFs and MK2206 inhibits EGF-gradient promoted motility. a MDA-MB-231: parallel iEFs and MK2206 work together to inhibit EGF-promoted migration speeds below levels of untreated controls. b iEFs and MK2206 work together to inhibit cell persistence significantly below levels of untreated control levels. c MCF10CA1a: co-treatment with iEFs and MK2206 significantly reduced migration speeds well below levels of untreated controls. d Co-treatment of MK2206 with iEFs increased persistence of these cancer cells. e MCF10A: co-treatment with iEFs and MK2206 inhibited EGF-promoted motility of normal breast cells. f The co-treatment resulted in increase in cell persistence compared with standalone MK2206 treatment. All data are presented as box plots show the minimum, 1st quartile, median, 3rd quartile, and maximum. All data pooled from three independent biological replicates for each condition. (Nonparametric independent samples Kruskal–Wallis test)