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. 2019 Aug 8;10(8):598. doi: 10.1038/s41419-019-1837-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The percentage of mo-MDSCs and G-MDSCs induced from WT or CXCR2−/− bone marrow cells were detected by flow cytometry. The bone marrow cells were treated with the serum of control mice, tumor-bearing mice (TB), tumor-bearing mice + 20 ng/mL CXCL1, or tumor-bearing mice +20 ng/mL CXCL2 in the presence of GM-CSF for 5 days in vitro. b, c Quantitative analyses of mo-MDSCs and G-MDSCs as shown in a. d The relative level of Arg1 and iNOS mRNA expression in mo-MDSCs was analyzed by qPCR. The mo-MDSCs were sorted from WT or CXCR2−/− bone marrow progenitor cells induced by the serum of control (control) or tumor-bearing mice (TB) for 5 days. The bars represent the mean ± SD of five independent experiments. A one-way ANOVA with repeated measures followed by a Dunnett’s post hoc test or two-way ANOVA followed by a Holm-Sidak’s post hoc test show the level of statistical significance (*p < 0.05; **p < 0.01; and ***p < 0.001; ns, not significant)