Fig. 1.

Pattern of accumulation of miR-H6 and miR-H1 during the time course of HSV-1 productive infection. A Underlined sequences indicate regions of complementarity between mature miR-H6-5p and H1-3p, H6-3p, and H1-5p. B, C Levels of miR-H6-5p, H1-3p, H6-3p, and H1-5p in HEp-2 cells exposed to 10 PFU of HSV-1(F) per cell with qPCR. Data shown are normalized to 18s rRNA. The two independent experiments were performed in triplicate. **P < 0.01, considered highly statistically significant. D Accumulation of miR-H6-5p, H6-3p, H1-5p, and H1-3p in the murine trigeminal ganglia during latency and upon reactivation from the latent state. miRNAs quantified and normalized with respect to the U6 cellular small RNA are shown as the fold change compared with miRNAs present in ganglia excised from mock-infected mice.