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. 2019 Aug 8;9:11506. doi: 10.1038/s41598-019-47743-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fourier transforms infrared spectral analysis. (A) Blank nanoparticles (without drug); (B) Polyvinyl alcohol (PVA); (C) polylactide-co-glycolide (PLGA); (D) Mixture of PLGA and PVA; (E) Drug, Lead Betulinic acid analogue, 2c; (F) Nanoparticles loaded with 2c; (G) Mixture of PLGA, PVA and 2c. Schematic representation of bond streaching of 2c, PLGA and PVA.