Table 1.
Biodistribution of 99mTc-2c-NP in Sprague Dawley rats and CRC Swiss albino mice with colorectal cancer.
| Organ/Tissue | %ID of 99mTc-2c-NP in CRC rats (SD) | %ID of 99mTc-2c-NP in CRC mice (SA) | ||||
|---|---|---|---|---|---|---|
| 1 h | 2 h | 5 h | 1 h | 2 h | 5 h | |
| Blood* | 2.138 ± 0.121 | 1.710 ± 0.094 | 0.809 ± 0.065 | 3.266 ± 0.055 | 2.698 ± 0.024 | 1.489 ± 0.015 |
| Heart | 1.522 ± 0.008 | 1.666 ± 0.014 | 1.717 ± 0.023 | 0.542 ± 0.038 | 0.481 ± 0.024 | 0.372 ± 0.042 |
| Liver | 42.84 ± 4.121 | 36.81 ± 5.368 | 26.66 ± 2.112 | 28.42 ± 2.162 | 21.14 ± 1.424 | 17.26 ± 1.722 |
| Lungs | 1.104 ± 0.092 | 1.780 ± 0.063 | 1.910 ± 0.024 | 1.000 ± 0.162 | 1.393 ± 0.123 | 1.660 ± 0.054 |
| Stomach | 1.322 ± 0.151 | 1.226 ± 0.096 | 1.369 ± 0.110 | 0.988 ± 0.151 | 1.246 ± 0.082 | 1.404 ± 0.120 |
| Spleen | 1.664 ± 0.101 | 1.824 ± 0.091 | 1.962 ± 0.072 | 1.892 ± 0.113 | 3.464 ± 0.288 | 4.114 ± 0.352 |
| Intestine | 3.042 ± 0.388 | 5.448 ± 0.741 | 6.101 ± 0.527 | 3.942 ± 0.164 | 4.155 ± 0.387 | 5.024 ± 0.671 |
| Kidney | 6.758 ± 1.102 | 7.134 ± 0.858 | 5.722 ± 0.761 | 8.758 ± 1.008 | 6.226 ± 0.716 | 4.175 ± 0.328 |
| Urine | 16.44 ± 2.743 | 21.23 ± 2.452 | 29.21 ± 4.52 | 10.44 ± 1.743 | 16.23 ± 1.826 | 26.45 ± 2.110 |
| Muscle* | 0.047 ± 0.009 | 0.062 ± 0.005 | 0.051 ± 0.010 | 0.051 ± 0.006 | 0.053 ± 0.008 | 0.071 ± 0.009 |
Results are expressed as percentage of injected dose per organ/tissue except blood and urine where it is expressed as percent injected dose per gram (marked as*). Each value represents mean ± SEM of five animals per group.