Table 5.
Impact of age of the patient, duration of disease and of time since infusion on the UPDRS scores ANCOVA model
| All population—ANCOVA model | Visit 2—year 1 | Visit 3—year 2 | ||||
|---|---|---|---|---|---|---|
| Mean change | 95% confidence Interval | p value | Mean change | 95% confidence interval | p value | |
| UPDRS item 39 | ||||||
| Age ( < = 70 vs > 70 years) | 0.01 | − 0.27 to 0.265 | 0.947 | 0.16 | − 0.11 to 0.43 | 0.242 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 0.15 | − 0.41 to 0.10 | 0.245 | − 0.20 | − 0.47 to 0.07 | 0.142 |
| Baseline | 0.798 | 0.153 | ||||
| Time since infusion (prospective vs retrospective) | 0.05 | − 0.21 to 0.31 | 0.694 | 0.14 | − 0.13 to 0.40 | 0.302 |
| UPDRS I ‘ON’ | ||||||
| Age ( < = 70 vs > 70 years) | 0.37 | − 0.64 to 1.38 | 0.473 | 0.32 | − 0.82 to 1.456 | 0.576 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 0.73 | − 1.72 to 0.27 | 0.151 | − 0.27 | − 1.39 to 0.85 | 0.633 |
| Baseline | 0.001 | 0.046 | ||||
| Time since infusion (prospective vs retrospective) | − 1.12 | − 2.16 to − 0.07 | 0.036 | − 1.72 | − 2.88 to − 0.56 | 0.004 |
| UPDRS I ’OFF’ | ||||||
| Age ( < = 70 vs > 70 years) | − 1.47 | − 2.89 to − 0.05 | 0.043 | − 1.24 | − 3.29 to 0.81 | 0.231 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | 0.91 | − 0.42 to 2.4125 | 0.177 | − 0.04 | − 1.91 to 1.84 | 0.967 |
| Baseline | < 0.001 | < 0.001 | ||||
| Time since infusion (prospective vs retrospective) | − 1.16 | − 2.47 to 0.15 | 0.081 | − 1.20 | − 3.01 to 0.60 | 0.187 |
| UPDRS II ’ON’ | ||||||
| Age ( < = 70 vs > 70 years) | 1.10 | − 1.59 to 3.78 | 0.420 | 1.23 | − 1.65 to 4.11 | 0.399 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 4.59 | − 7.30 to − 1.88 | 0.001 | − 4.09 | − 6.99 to − 1.19 | 0.006 |
| Baseline | < 0.001 | < 0.001 | ||||
| Time since infusion (prospective vs retrospective) | − 3.52 | − 6.25 to − 0.78 | 0.012 | − 3.53 | − 6.46 to − 0.59 | 0.019 |
| UPDRS II ‘OFF’ | ||||||
| Age ( < = 70 vs > 70 years) | − 2.95 | − 6.29 to 0.39 | 0.083 | − 1.53 | − 5.11 to 2.04 | 0.396 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 2.25 | − 5.52 to 1.02 | 0.175 | − 3.08 | − 6.59 to 0.42 | 0.084 |
| Baseline | < 0.001 | < 0.001 | ||||
| Time since infusion (prospective vs retrospective) | − 2.44 | − 5.79 to 0.92 | 0.152 | − 1.95 | − 5.54 to 1.65 | 0.284 |
| UPDRS IV (A + B) | ||||||
| Age ( < = 70 vs > 70 years) | 0.32 | − 0.72 to 1.36 | 0.545 | 1.18 | 0.16 to 2.21 | 0.024 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 0.89 | − 1.93 to 0.15 | 0.094 | − 1.22 | − 2.24 to − 0.19 | 0.020 |
| Baseline | 0.005 | < 0.001 | ||||
| Time since infusion (prospective vs retrospective) | − 0.63 | − 1.68 to 0.42 | 0.236 | − 0.60 | − 1.62 to 0.43 | 0.254 |
| UPDRS Dyskinesia score: ITEM 32 | ||||||
| Age ( < = 70 vs > 70 years) | 0.19 | − 0.13 to 0.50 | 0.246 | 0.41 | 0.06 to 0.76 | 0.020 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 0.13 | − 0.45 to 0.18 | 0.591 | − 0.23 | − 0.58 to 0.11 | 0.186 |
| Baseline | 0.001 | 0.015 | ||||
| Time since infusion (prospective vs retrospective) | − 0.09 | − 0.41 to 0.23 | 0.591 | 0.02 | − 0.32 to 0.37 | 0.895 |
| UPDRS Dyskinesia score: ITEM 33 | ||||||
| Age ( < = 70 vs > 70 years) | 0.12 | − 0.25 to 0.49 | 0.527 | 0.45 | 0.11 to 0.80 | 0.011 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | − 0.11 | − 0.49 to 0.26 | 0.544 | − 0.14 | − 0.48 to 0.21 | 0.443 |
| Baseline | 0.050 | 0.081 | ||||
| Time since infusion (prospective vs retrospective) | − 0.48 | − 0.85 to − 0.11 | 0.012 | − 0.4 | − 0.69 to 0.01 | 0.055 |
| UPDRS Dyskinesia score: ITEM 34 | ||||||
| Age ( < = 70 vs > 70 years) | 0.021 | − 0.22 to 0.25 | 0.899 | 0.06 | − 0.19 to 0.30 | 0.658 |
| Time since PD diagnosis ( < = 13 vs > 13 years) | 0.06 | − 0.18 to 0.29 | 0.636 | − 0.13 | − 0.38 to 0.12 | 0.300 |
| Baseline | < 0.001 | < 0.001 | ||||
| Time since infusion (prospective vs retrospective) | − 0.14 | − 0.38 to 0.09 | 0.232 | 0.02 | − 0.23 to 0.27 | 0.873 |
Variables in bold are statistical significant for at least p < 0.05