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. 2019 Aug 8;9:11519. doi: 10.1038/s41598-019-47993-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with KUS121 improves functional deficits and reduces brain infarction volume. (a) Rotarod retention time and (b) the time to remove an adhesive tape in C57BL/6 mice subjected to transient occlusion of the distal portion of left middle cerebral artery (MCA). Neurological function was measured by the accelerating rotarod apparatus and adhesive removal test 24 h after occlusion of the distal MCA (n = 16; *p < 0.05). (c) Quantification of the infarction volume was calculated by Nissl staining and representative Nissl stained brain sections of C57BL/6 mice (Scale bar: 1,000 μm; vehicle, n = 5; KUS121, n = 4; *p < 0.05). (d) Quantification of the infarction volume in B-17 mice measured 24 h after transient occlusion of the distal MCA and calculated by Nissl staining (vehicle, n = 4; KUS121, n = 5; *p < 0.05). (e) Western blot analyses of cerebral cortex lysates for Neuronal Nuclei (NeuN) and myelin basic protein (MBP). The cerebral cortex of B-17 mice was collected 24 h after transient occlusion of the distal MCA. The ratio of NeuN or MBP to β-actin expression levels was calculated (n = 5; *p < 0.05).