Table 4.

Summary of results from the global glymphatic transport analysis

Age (wk)	Strain	N	K1 (ml · cm−3 · min−1)	k2 (min)	VECS (%)	VCSF (%)	Fit RMSE (mmol/cm3)
7–9	WKY	9	0.0069 ± 0.0017	0.0242 ± 0.006	29.5 ± 6.8	5.4 ± 2.1	0.0016 ± 0.0011
	SHR	6	0.0049 ± 0.0014**a	0.0226 ± 0.007	22.0 ± 2.7*d	4.0 ± 3.1	0.0012 ± 0.0005
19–21	WKY	5	0.0058 ± 0.0008	0.0205 ± 0.002	28.5 ± 5.2	6.9 ± 2.2	0.0012 ± 0.0001
	SHR	7	0.0037 ± 0.0011*b	0.0151 ± 0.004*c	24.8 ± 4.9	4.4 ± 1.7	0.0011 ± 0.0001

*p < 0.05;

**p < 0.01; K₁, k₂; one-tailed Mann–Whitney U tests (SHR < WKY); V_ECS, V_CSF: two-tailed Mann–Whitney U tests;

^ap = 0.0088;

^bp = 0.015;

^cp = 0.036;

^dp = 0.0027.