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The 28S subunit and mitochondrial disease. Schematic representation of the mitochondrial 28S subunit with circles representing each of the 30 constituent proteins. Numbers in the circles are specific MRPS associated with mitochondrial disease. Defects in MRPS16, MRPS22 and MRPS25, closely juxtaposed in the 28S subunit, are associated with agenesis of corpus callosum.
