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. 2019 May 15;28(16):2752–2762. doi: 10.1093/hmg/ddz095

Figure 7.

Figure 7

Nf1/Arf mutant mice die from tumor progression to MPNST. (A) Nf1flox/flox;Arfflox/flox;PostnCre(+) mouse with multiple, rapidly growing and infiltrative masses. A diagnosis of MPNST was confirmed histopathologically post-mortem. (B) PN arising from a thoracic nerve root in a representative Nf1flox/flox;Arfflox/flox;PostnCre(+) mouse. Progression to ANNUBP is observed with hypercellularity, cellular atypia and a fascicular growth pattern. Subsequent transition to MPNST with encasement/invasion of surrounding rib and multiple mitotic figures is seen. (C) Kaplan Meier survival curve of WT (n = 14), Arf flox/flox;PostnCre(+) (n = 9) Nf1flox/flox (n = 17), Nf1flox/flox;Arf flox/+;PostnCre(+) (n = 17) and Nf1flox/flox;Arf flox/flox;PostnCre(+) (n = 16) mice. Statistical analysis was performed using a logrank test with Bonferroni post hoc adjustment for multiple comparisons. ***P < 0.001 Nf1flox/flox;Arfflox/flox;PostnCre(+) versus WT, Arfflox/flox;PostnCre(+) and Nf1flox/flox;PostnCre(+). **P < 0.01 Nf1flox/flox;Arfflox/flox;PostnCre(+) versus Nf1flox/flox;Arf flox/+;PostnCre(+).