Table S2. Baseline data for pooled patient cohort. Groups are compared using risk difference and mean difference with heterogeneity statistic and confidence interval included.
| Characteristic | Total cohort, n (%, 95% CI) | TEVAR, n (%, 95% CI) | Medical management, n (%, 95% CI) | RD, MD (95% CI) | I2, % [95% CI] | P |
|---|---|---|---|---|---|---|
| Patients | 327 | 161 | 166 | – | – | – |
| Males | 184/271 (67, 61–72.5) | 88/121 (72.1, 61.9–80.4) | 61/93 (65, 54.5–74.2) | 0.102 (−0.0186–0.223) | 0 [0–0] | 0.097 |
| Age, mean (95% CI), n (years) | 62.2 (55.8–68.7), n=327 | 62.6 (53.8–71.3), n=161 | 61.9 (51.7–72.1), n=166 | 0.495 (−1.613–2.602) | 0 [0–38] | 0.645 |
| Hypertension | 179/204 (86, 75.2–92.6) | 72/84 (84.4, 69.3–92.8) | 51/63 (77.6, 56.4–90.3) | 0.0322 (−0.258–0.322) | 82 [44–94] | 0.828 |
| Diabetes mellitus | 21/204 (10.7, 7.07–15.9) | 8/84 (9.81, 4.98–18.4) | 7/63 (11.9, 5.75–22.9) | −0.0080 (−0.109–0.0935) | 0 [0–88] | 0.878 |
| COPD | 39/162 (24.5, 15.7–36) | 23/84 (28.1, 15.5–45.5) | 14/63 (21.7, 7.85–47.4) | 0.0767 (−0.0505–0.204) | 0 [0–62] | 0.237 |
| Ischaemic heart disease | 26/139 (19.7, 11.5–31.8) | 10/50 (20.7, 11.5–34.4) | 5/32 (15.6, 6.66–32.5) | 0.0285 (−0.137–0.194) | 0 [0–0] | 0.735 |
| Renal impairment | 16/147 (12.3, 7.63–19.1) | 11/84 (13.6, 7.68–23) | 5/63 (9.53, 3.78–22) | 0.0517 (−0.0386–0.142) | 0 [0–70] | 0.262 |
| History of aortic surgery | 14/124 (11.8, 7.1–19) | 4/50 (8.05, 3.05–19.6) | 4/32 (13.1, 4.99–30.2) | −0.0314 (−0.163–0.101) | 0 [0–0] | 0.641 |
| Symptomatic presentation | 153/160 (93, 83.1–97.3) | 77/80 (92.7, 82.9–97.1) | 76/80 (93.7, 68.3–99) | 0.0141 (−0.0623–0.0906) | 29 [0–74] | 0.717 |
| Penetrating atheromatous ulcer | 52/164 (33.4, 16.5–55.9) | 51/117 (51.2, 27.3–74.6) | 1/47 (7.3, 2.05–22.8) | 0.565 (0.240–0.889) | 85 [63–94] | 0.001 |
| Ulcer-like projection | 18/97 (19.7, 9.89–35.5) | 16/55 (29.7, 19–43.3) | 2/42 (5.94, 1.73–18.5) | 0.240 (0.0965–0.384) | 0 [0–89] | 0.001 |
| MAD, mean (95% CI), n (mm) | 40.4 (37.1–43.8), n=213 | 40.8 (36.7–44.8), n=117 | 37.3 (33.4–41.3), n=86 | 3.46 (−2.02–8.93) | 81 [41–94] | 0.216 |
| IMH size, mean (95% CI), n (mm) | 13.1 (10.1–16), n=213 | 15.9 (13–18.8), n=117 | 10.5 (7.66–13.3), n=86 | 5.47 (0.320–10.6) | 92 [79–97] | 0.037 |
COPD, chronic obstructive pulmonary disease; MAD, maximum aortic diameter; IMH, intramural hematoma; TEVAR, transcatheter endovascular aortic repair; CI, confidence interval; RD, risk difference; MD, mean difference; I2, heterogeneity statistic; P, alternate hypothesis probability.