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. 2019 Aug 2;9:630. doi: 10.3389/fonc.2019.00630

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Copyright © 2019 Pollard, Suckow, Wolter, Starr, Eidelman, Dalgard, Kumar, Battacharyya, Srivastava, Biswas, Wilkerson, Zhang, Yang and Pollard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stagger plots show effect of digitoxin on diameters of metastatic sites on pleural surface which have seeded from primary tumors. (A) Distribution of individual metastasis diameters in control (no drug treatment) rats. There are 15 such rats in the plot. (B) Distribution of individual metastasis diameters in treated (treatment with digitoxin) rats. There are 15 control rats in the plot. (C) Histogram of size distribution for metastases from a representative control rat Distribution is multimodal. (D) Histogram of size distribution for metastases from a representative digitoxin-treated animal. The distribution is monomodal.