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. 2019 Aug 2;9:630. doi: 10.3389/fonc.2019.00630

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Copyright © 2019 Pollard, Suckow, Wolter, Starr, Eidelman, Dalgard, Kumar, Battacharyya, Srivastava, Biswas, Wilkerson, Zhang, Yang and Pollard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of digitoxin treatment on number and size of lung metastases from tumor cells implanted intravenously. (A) Number of lung metastases following intravenous administration of tumor cells. Color code: red = digitoxin; blue vehicle control. Medians are identical P, 2 tailed = 0.492; N, digitoxin = 13; N, control = 14. (B) Area occupied by lung metastases following intravenous administration of tumor cells. Color code the same as in part A. Significantly less area occupied by tumor cells in digitoxin-treated rats (P, 2 tailed = 0.004; N, digitoxin = 11; N, control = 12). (C) Bar plot for data in Part A. (D) Bar plot for data in Part B.