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. 2019 Aug 2;9:630. doi: 10.3389/fonc.2019.00630

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Copyright © 2019 Pollard, Suckow, Wolter, Starr, Eidelman, Dalgard, Kumar, Battacharyya, Srivastava, Biswas, Wilkerson, Zhang, Yang and Pollard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of digitoxin treatment on survival following tumor resection. Following subcutaneous implantation of tumor cells into 30 rats, digitoxin administration was initiated on 15 of the rats 10 days later. Eight days late, all tumors were resected. Surviving digitoxin-treated rats received daily digitoxin treatment for duration of the experiment. All surviving control (no digitoxin treatment) rats experienced tumor recurrence and all had expired by ca. day 50. However, by day 80, 30% of digitoxin-treated rats were still surviving a grossly tumor free when necropsied. Kaplan-Meier Survival Curves were significantly different based on a log rank Mantel-Cox Chi-Square test (p, 2 tailed = 0.035).