Table 2.
Clinical characteristics of asthmatics stratified by ICSa
| ICS a (total μg/day)* | |||
|---|---|---|---|
| ICS a (total μg/day) | <1000 | >1000 | |
| Number | 13 | 5 | P value |
| Total daily dose ICS a (μg/day) | 282 | 1097 | 7.1E−07 |
| Sex (% F) | 62 (8/13) | 40 (2/5) | 0.440 |
| Age | 41.5 | 38.0 | NS |
| Body mass index (BMI) | 39.58 | 39.17 | NS |
| IgE (kU/L) | 114.6 | 521.8 | 0.076 |
| History of smoking (%) | 38 | 60 | NS |
| Pack year | 2.8 | 12.2 | 0.031 |
| Currently smoking (%) | 0 | 0 | NS |
| FEV1 c (% Pred) | 85.8 | 68.4 | 0.016 |
| FEV1/FVC b | 70.8 | 60.6 | 0.093 |
| Oral corticosteroid (%) | 8.0 | 20 | NS |
| Short‐acting β agonist (%) | 20 | 20 | NS |
| Long‐acting β agonist (%) | 54 | 100 | NS |
| Montelukast (%) | 8 | 20 | NS |
| Severe asthma (%) d | 0 | 80 | 0.001 |
| Eosinophils (%) f | 4.04 | 2.56 | NS |
| Neutrophils (%) f | 61.85 | 53.73 | NS |
| % CD4+ T cells | 5.31 | 8.77 | 0.053 |
| % CD4+ CRTh2+ | 4.74 | 4.49 | NS |
| % CD4+ CRTh2+/WBC e | 0.22 | 0.36 | 0.036 |
| IL‐13 (pg/mL) | 408.74 | 540.97 | 0.418 |
| IL‐2 (pg/mL) | 29, 687.74 | 57 890.33 | 0.030 |
Abbreviations: ICS, inhaled corticosteroids; IgE,immunoglobulin E; WBC, white blood cells. Bold text denotes p value <0.05.
*
Data stratified by 1000 μg/day.
a
ICS, inhaled corticodsteroid, fluticasone equivalent.
b
FVC, forced vital capacity.
c
FEV1, forced expiratory volume in 1 second.
d
ATS/ERS Guidelines.15
e
WBC, peripheral white blood cells.
f
Percent of complete blood count.