. 2019 Sep;31(9):600–610. doi: 10.1016/j.clon.2019.05.002

Table 1.

Late toxicity assessed using Radiation Therapy Oncology Group (RTOG), Royal Marsden Hospital (RMH) and Late Effects on Normal Tissues: Subjective: Objective/Management (LENT/SOM) scoring systems: bowel toxicity (in rectum volume matched dataset) and bladder toxicity (in bladder volume matched dataset)

Grade		Rectum volume matched dataset						Bladder volume matched dataset
		RTOG bowel		RMH bowel		LENT/SOM bowel		RTOG bladder		RMH bladder		LENT/SOM bladder
		FP	IP	FP	IP	FP	IP	FP	IP	FP	IP	FP	IP
		n = 53	n = 53	n = 53	n = 53	n = 53	n = 53	n = 61	n = 61	n = 61	n = 61	n = 61	n = 61
		n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)
6 months	0	44 (90)	46 (87)	43 (88)	47 (90)	38 (78)	43 (81)	59 (98)	57 (93)	40 (67)	40 (66)	43 (72)	31 (51)
	1	3 (6)	7 (13)	4 (8)	5 (10)	9 (18)	7 (13)	0	4 (7)	16 (27)	19 (31)	10 (17)	21 (34)
	2	2 (4)	0	2 (4)	0	1 (2)	2 (4)	1 (2)	0	3 (5)	2 (3)	6 (10)	8 (13)
	3	0	0	0	0	1 (2)	1 (2)	0	0	1 (2)	0	1 (2)	1 (2)
	4	0	0	0	0	0	0	0	0	0	0	0	0
	Not assessed	4	0	4	1	4	0	1	0	1	0	1	0
Mann–Whitney P value		0.701		0.628		0.699		0.188		0.985		0.036
12 months	0	44 (88)	45 (85)	35 (70)	46 (87)	33 (67)	40 (76)	56 (97)	58 (95)	36 (62)	41 (67)	42 (72)	29 (48)
	1	4 (8)	7 (13)	13 (26)	6 (9)	13 (27)	11 (21)	1 (2)	2 (3)	18 (31)	17 (28)	10 (17)	25 (41)
	2	2 (4)	1 (2)	1 (2)	1 (2)	2 (4)	2 (4)	1 (2)	1 (2)	1 (2)	2 (3)	4 (7)	6 (10)
	3	0	0	1 (2)	1 (2)	1 (2)	0	0	0	3 (5)	1 (2)	2 (4)	1 (2)
	4	0	0	0	0	0	0	0	0	0	0	0	0
	Not assessed	3	0	3	0	4	0	3	0	3	0	3	0
Mann–Whitney P value		0.690		0.047		0.350		0.697		0.524		0.016
18 months	0	39 (81)	49 (94)	35 (73)	46 (89)	32 (67)	46 (89)	50 (93)	56 (93)	34 (62)	38 (63)	38 (72)	35 (59)
	1	7 (15)	2 (4)	11 (23)	5 (10)	10 (21)	4 (8)	3 (6)	3 (5)	19 (35)	20 (33)	4 (8)	18 (31)
	2	2 (4)	1 (2)	1 (2)	1 (2)	4 (8)	2 (4)	1 (2)	0	1 (2)	1 (2)	9 (17)	5 (9)
	3	0	0	1 (2)	0	2 (4)	0	0	1 (2)	1 (2)	0	2 (4)	0
	4	0	0	0	0	0	0	0	0	0	1 (2)	0	1 (2)
	Not assessed	5	1	5	1	5	1	7	1	6	1	8	2
Mann–Whitney P value		0.049		0.050		0.008		0.883		0.866		0.460
24 months	0	44 (90)	48 (96)	33 (67)	44 (88)	32 (65)	42 (86)	51 (94)	56 (98)	37 (69)	39 (68)	34 (63)	34 (60)
	1	5 (10)	1 (2)	15 (31)	5 (10)	14 (19)	6 (12)	3 (6)	0	14 (26)	14 (25)	10 (19)	17 (30)
	2	0	1 (2)	1 (2)	1 (2)	2 (4)	1 (2)	0	1 (2)	2 (4)	3 (5)	9 (17)	4 (7)
	3	0	0	0	0	1 (2)	0	0	0	1 (2)	1 (2)	1 (2)	2 (4)
	4	0	0	0	0	0	0	0	0	0	0	0	0
	Not assessed	4	3	4	3	4	4	7	4	5	4	7	4
Mann–Whitney P value		0.247		0.016		0.019		0.298		0.954		0.984

FP, forward planned; IP, inverse planned.