Figure 2.

Schematic structures of representative factor H family proteins, their interactions with pentraxins CRP and PTX3 and disease associations. The pentraxin interacting domains in FH family proteins (marked above) display disease-associated polymorphisms that alter the protein/pentraxin interactions. The substituted amino acid are marked below. The asterisk indicates the pentraxin, whose binding to the protein is affected by the polymorphism. FHR-2 and FHR-3 are not shown, because their plasma concentrations are low. AMD, Age-related Macular Degeneration; DDD, Dense Deposit Disease; aHUS, atypical Hemolytic Uremic Syndrome; PTX, pentraxin; CRP, C-reactive protein; mCRP, monomeric CRP; pCRP, pentameric CRP.