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. 2019 Aug 2;7:147. doi: 10.3389/fcell.2019.00147

FIGURE 3.

FIGURE 3

Proposed membrane topology of human LPAATδ. The transmembrane domains (TMD; in turquoise) were predicted by CCTOP prediction server (http://cctop.enzim.ttk.mta.hu) (Dobson et al., 2015) and indicated as TMD1 (amino acids 15-38), TMD2 (amino acids 308-327), and TMD3 (amino acids 333-352). The four Catalytic Motifs of LPAATδ are indicated as I-IV in purple, and their amino acid sequences are reported in the sequence alignment as Motif I (amino acids 93-103), Motif II (amino acids 140-146), Motif III (amino acids 173-182), and Motif IV (amino acids 204-209). Highly conserved proline P130 and glycine G133 in the PxxG motif between catalytic motifs I and II are highlighted. Lysines K123 and K124 are highlighted. The N-terminus of the protein is predicted to be located in the lumen while the C-terminus is predicted to be located in the cytoplasm (as indicated).