FIGURE 2.

Molecular docking diagrams showing the bonding interactions between the phendione compounds and the lasB-encapsulated HPI/lasB active site of P. aeruginosa. Docking of phendione (A), Ag-phendione (C) and Cu-phendione (E) with the N-(1-carboxy-3-phenylpropyl)phenylalanyl-α-asparagine moiety illustrated using ball and stick models, and π-stacking interactions are highlighted in red dashed lines. Hydrogen bonds between lasB, water molecules and phendione (B), Ag-phendione (D) and Cu-phendione (F) are shown with blue dashed lines.