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Serotonin promotes a glial-to-neuronal fate change in vitro. A, EdU incorporation was observed in glial and double immunoreactive cells (open arrows) but not neurons (solid arrow). Although control cultures contained many neurons (B and D), addition of a 5-HT4 antagonist (GR) decreased neuronal density and increased the proportion of biphenotypic neuroglial cells (C and D). *P < 0.05.
