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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: Peptides. 2017 Feb 10;90:10–16. doi: 10.1016/j.peptides.2017.02.001

Fig. 1.

Fig. 1.

Influence of angiotensin receptor antagonists on the vasorelaxant response to Ang-(1–7) in the renal artery. Linear plots of percent vasorelaxation (%) and the log dose of Ang-(1–7) alone or with various antagonists. Panel A: effect of [D-Ala1]-Ang-(1–7) (DALA,10−5 M), [D-Pro1]-Ang-(1–7) (DPRO, 10−5 M) or denuding endothelium (-END) on Ang-(1–7)-induced vasodilation (10−12–3 × 10−6 M) of the isolated renalartery of the rat. Panel B: effect of [Sar1,Thre8]-Ang II (Sarthran, 10−5 M), losartan (10−6 M) and PD123319 (10−6 M) on Ang-(1–7)-induced vasodilation (10−12 to 3 × 10−6 M) of the isolated renal artery of the rat. Data are mean ± SEM (n = 4–10 per group, see Table 1) compared to Ang-(1–7) alone by ANOVA with Dunnett’s post hoc test. *P < 0.05 versus Ang-(1–7) from 10−11 to 3 × 10−6 M; #P < 0.05 versus Ang-(1–7)from 10−8 to 3 × 10−6 M.