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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Curr Opin Microbiol. 2018 Oct 23;46:109–115. doi: 10.1016/j.mib.2018.10.002

Figure 2.

Figure 2

Reticulocyte maturation and susceptibility to parasite invasion. CD34+ hematopoietic stem cells (HSCs) mature in the bone marrow lumen to form orthochromatic erythroblasts. These cells undergo a process of enucleation, producing a nascent reticulocyte and a pyrenocyte. Reticulocytes continue to mature initially in the bone marrow and subsequently in the peripheral circulation, eventually forming mature RBCs. Schematic levels of transferrin receptor (TfR) and susceptibility of cells to P. vivax and P. falciparum is indicated.