Table 3.
Details of different SQTS types treated by HQ.
| Case | Author | Sex | Gene | Mutation | Current | Symptoms | Arrhythmias | Type of SQTS | Drugs | Side effects | Outcome | QTc before drug (ms) | QTc on drugs (ms) | Follow-up days |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | (El-Battrawy et al., 2018) | F | KCNH2 | N588K | IKr | Palpitation | Atrial fibrillation | SQTS1 | HQ | None | No VA and no inducible arrhythmias in EP study anymore | 351 | 435 | 5564 |
| 2 | F | KCNH2 | N588K | IKr | None | None | SQTS1 | HQ | None | No VA and no inducible arrhythmias in EP study | 268 | 400 | 5427 | |
| 3 | M | KCNH2 | N588K | IKr | Syncope | Atrial fibrillation | SQTS1 | HQ | None | No shocks while on HQ more | 329 | — | 4572 | |
| 4 | M | CaCNA1C | G490R | ICa-L | Palpitation | Atrial fibrillation | SQTS4 | HQ | None | HQ treatment stopped (no compliance) | 347 | 446 (HQ) | 4720 | |
| 5 | M | CaCNB2B | C1422T | ICa-L | Syncope SCD | Atrial fibrillation Atrial flutter |
SQTS5 | HQ | None | Two inappropriate shocks while with HQ | 329 | 373 | 5756 | |
| 6 | M | — | — | — | Palpitation | Atrial fibrillation Atrial flutter |
SQTS | HQ+Ve | None | HQ treatment stopped (no compliance) | 326 | 449 (HQ+Ve) | 5195 | |
| 7 | (Bun et al., 2012) | M | — | — | — | SCD | VF | SQTS | HQ | None | No recurrence of VA | 320 | — | 180 |
| 8 | (Mazzanti et al., 2017) | M | — | — | — | Syncope | None | SQTS | HQ | None | No LTA after initiating HQ | 312 | 398 | 2310 |
| 9 | M | — | — | — | None | None | SQTS | HQ | None | No VA | 314 | 350 | ||
| 10 | F | KCNQ1 | R259H | IKs | SCD | None | SQTS2 | HQ | None | No VA | 316 | 405 | ||
| 11 | M | — | — | — | None | None | SQTS | HQ | None | No VA | 321 | 412 | ||
| 12 | M | — | — | — | SCD | None | SQTS | HQ | None | No VA | 324 | 418 | ||
| 13 | F | — | — | — | None | None | SQTS | HQ | None | No VA | 326 | 356 | ||
| 14 | M | KCNJ2 | D172N | Ik1 | None | None | SQTS3 | HQ | None | No VA | 332 | 396 | ||
| 15 | M | — | — | — | Syncope | None | SQTS | HQ | None | No VA | 337 | 388 | ||
| 16 | M | — | — | — | None | None | SQTS | HQ | None | No VA | 338 | 390 | ||
| 17 | M | — | — | — | SCD | None | SQTS | HQ | None | No VA | 338 | 398 | ||
| 18 | M | — | — | — | None | None | SQTSn | HQ | None | No VA | 339 | 358 | ||
| 19 | M | — | — | — | None | None | SQTS | HQ | None | No VA | 340 | 382 | ||
| 20 | M | — | — | — | SCD | None | SQTS | HQ | None | No VA | 344 | 413 | ||
| 21 | M | — | — | — | SCD | None | SQTS | HQ | None | No VA | 348 | 390 | ||
| 22 | M | — | — | — | SCD | None | SQTS | HQ | None | No VA | 351 | 410 | ||
| 23 | (Suzuki et al., 2014) | M | KCNH2 | N588K | IKr | None | None | SQTS1 | HQ | None | — | 283 | 341 | — |
| 24 | (Guistetto et al., 2015) | M | KCNH2 | T618I | IKr | None | Ventricular ectopy | SQTS1 | HQ | None | Ventricular ectopy has been suppressed | 300 | 333 | 1770 |
| 25 | F | KCNH2 | T618I | IKr | None | None | SQTS1 | HQ | None | Loops recorder detected one slow nsVT | 340 | 389 | 1770 | |
| 26 | F | KCNH2 | T618I | IKr | SCD | nsVT | SQTS1 | HQ | None | Still runs of nsVT but slower on HQ | 355 | 411 | 1770 |
EP, electrophysiology; —, not documented; SCD, sudden cardiac death; Bis VE, verapamil; ME, metoprolol; Bi, bisoprolol.