Table.

Research Plan for the NIH HEAL Initiative

Opportunities	Components
Improving Treatments for Opioid Misuse and Addiction
New treatments for addiction	Identify new targets, develop new medications/immunotherapies; reformulate existing medicines
	Improve overdose reversal medicines
	Develop new therapies for opioid-induced respiratory depression
Optimization of effective treatments for addiction	Enhance NIDA Clinical Trials Network for opioid research
	Establish Justice Community Opioid Intervention Network
	Initiate HEALing Communities Study
NOWS	Expand ACT NOW pilot study; use results to conduct clinical trials to determine best practices for clinical care of NOWS
Enhancing Pain Management
Better understanding of chronic pain	Establish Acute to Chronic Pain Signatures program
New nonaddictive pain treatments	Identify new targets for pain treatment
	Engineer preclinical testing platforms to profile potential nonaddictive treatments
Public-private HEAL Partnership to speed movement of nonaddictive treatments through clinical pipeline	Enhance data and asset sharing
	Validate biomarkers to inform neurotherapeutic and pain clinical research
	Establish clinical trials network to support and accelerate trials of nonaddictive pain therapies

Abbreviations: HEAL, Helping to End Addiction Long-term; NIDA, National Institute on Drug Abuse; NIH, National Institutes of Health; NOWS, neonatal opioid withdrawal syndrome.