Fig. 7.

HDAC inhibitor suppresses LPC-induced demyelination and enhances remyelination. a MBP and NF200 immunocytochemical staining of organotypic cerebellar slice cultures with or without butyrate or TSA treatment in the remyelination phase. Scale bar, 100 μm. b Myelination index (MI) of organotypic cerebellar slice cultures (n = 9 slices per group, pooled from three independent experiments). c MBP and NF200 immunocytochemical staining of organotypic cerebellar slice cultures with or without butyrate or TSA treatment in the demyelination phase. Scale bar, 100 μm. d MI of organotypic cerebellar slice cultures (n = 9 slices per group, pooled from three independent experiments). The box plot indicates the first and third quartiles and the middle line indicates the median. Whiskers indicate the minimum and maximum. **p < 0.01, ***p < 0.001