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. 2019 Aug 2;10:831. doi: 10.3389/fneur.2019.00831

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Copyright © 2019 Okonkwo, Puffer, Minhas, Beers, Edelman, Sharpless, Laymon, Lopresti, Benso, Puccio, Pathak, Ikonomovic, Mettenburg, Schneider, Mathis and Mountz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serial transverse brain sections from (A) structural MRI, (B) NeuroReader segmentation, (C) [¹⁸F]AV-1451 PET, (D) [¹¹C]PiB PET, and (E) [¹⁸F]FDG PET for Patient #2. (A,B) Quantitative analysis of the MRI scan demonstrated normal volumes. (C) The [¹⁸F]AV-1451 PET scan is most significant for demonstrating abnormal intensely increased symmetric uptake in the precuneus (FreeSurfer mean [FS] SUVR: 2.97), superior parietal (FS SUVR: 2.86), and lateral occipital regions (FS SUVR: 2.76). There is also abnormally increased uptake in the lateral inferior temporal (FS SUVR: 2.47), entorhinal (FS SUVR: 2.13), lateral orbitofrontal (FS SUVR: 1.78), and superior frontal (FS SUVR: 1.67) regions. (D) The [¹¹C]PiB PET scan demonstrates significant abnormally increased uptake in parietal, temporal and frontal lobes, as in Patient #1, demonstrating a pattern characteristic of AD. Note there is negligible accumulation in the occipital lobes (as compared to the [¹⁸F]AV-1451 scan). (E) The [¹⁸F]FDG PET scan shows abnormally and relatively symmetric decreased uptake in the posterior temporoparietal regions of the brain, with sparing of the frontal lobes.