Table 3.
Clinical outcomes during the course of anticoagulant therapy
| Pulmonary embolism | Deep vein thrombosis | Rate ratio (95%CI) |
|||
|---|---|---|---|---|---|
| N | Events per 100 patient-years |
N | Events per 100 patient-years |
||
| Patients, N | 14 | 9 | |||
| Recurrent PE | 0 | – | 0 | – | – |
| Recurrent DVT | 0 | – | 1 | 16.67 (0. 22-92.72) | – |
| Major bleeding | 1 | 10.02 (0. 13-55.75) | 1 | 16.67 (0. 22-92.72) | 0.60 (0.04–9.61) |
| Site of major bleeding (days) a , | |||||
| Epistaxis (32b) | 0 | – | 1 | 16.67 (0. 22-92.72) | – |
| GI (534) | 1 | 10.02 (0. 13-55.75) | 0 | – | – |
| Non-major bleeding | 3 | 30.06 (6.04–87.83) | 3 | 50 (10.05–146.1) | 0.60 (0. 12-2.98) |
| Site of minor bleeding (days) a , | |||||
| Epistaxis (9,31,179) | 3 | 30.06 (6.04–87.83) | 0 | – | – |
| Others (0b,5,50) | 0 | – | 3 | 50 (10.05–146.1) | – |
| Death | 1 | 10.02 (0. 13-55.75) | 0 | – | – |
| Causes of death, | |||||
| Respiratory insufficiency | 1 | 10.02 (0. 13-55.75) | 0 | – | – |
Abbreviations: PE pulmonary embolism, DVT deep vein thrombosis; 95%CI, 95% confidence intervals, GI gastrointestinal
a Days from index VTE diagnosis to bleeding event
b Receiving LMWH < 100 IU/kg/day