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. 2019 Aug 2;9:717. doi: 10.3389/fonc.2019.00717

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Copyright © 2019 Ma, Zhang, Wang, Huang, Kuai, Zhu, Chen, Jia, Feng, Tang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferation of differentially c-Met-expressing cell lines detected using IC50 dose-response curves with the Cell Counting Kit-8 assay. (A) The proliferation of shMet-HepG2 cells decreased after treatment with oxaliplatin, while no significant effect was observed in the group exposed to humanized IgG or the conjugates after 24 h. (B) Oxaliplation and anti-c-Met-OXA inhibited the proliferation of the HepG2 cell line, and anti-c-Met IgG had no significant effect on cell proliferation. Statistical analysis was made of the inhibition ratio data at the maximum concentration among groups. Data are expressed as the logarithm change (average ± SD) from 5 random fields. NS, non-significant. *P < 0.05, ***P < 0.001 vs. “anti-c-Met IgG” as determined by ANOVA.