Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 9;19:59. doi: 10.1186/s12896-019-0553-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 8 — Structural analysis of Ph-HepI wild-type and mutant enzymes. (a) In the wild-type, Ser169 forms two hydrogen bonds with Leu172 and Glu228. (b) In the mutant S169D, Asp169 forms three hydrogen bonds with adjacent amino acids (Leu172, Glu228, and Asp353) and forms an ionic bond with the calcium ion. (c) In the wild-type, Ala259 forms two hydrogen bonds with Asp257 and Arg261. (d) In the mutant A259D, Asp259 forms three hydrogen bonds with Tyr89, Asp257, and Arg261