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. 2019 Aug 9;38:348. doi: 10.1186/s13046-019-1334-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — TET1 reverses EMT progress via the Wnt/β-catenin signaling pathway. a and b RNA array analysis of 84 EMT-associated genes in BX-TET1-OE and BX-TET1-NC cells, shown as a heatmap (log2-fold changes). c Heatmap (fold changes) of Wnt/β-catenin, TGF-β, and NOTCH signaling pathway changes in BX-TET-OE and SW1990-KO cells comparing respective negative controls. d Western blot analysis of key changes in gene expression in the Wnt/β-catenin pathway in BX-TET1-OE and BX-TET1-NC cells. e Western blot analysis of total β-catenin distribution in BXPC-3 and SW1990 cells. f Immunofluorescence staining of intracellular migration of active β-catenin in BX-TET1-OE and BX-TET1-NC cells