Table 2.

piRNAs as biomarkers in cancer

piRNA	Cancer	Expression in blood	Clinical correlation	ROC curve AUC sensitivity specifity	Reference
piR-651	Gastric cancer	down	TNM stage, distant metastasis	0.841 0.709 0.813	[101]
piR-823		down	TNM stage, distant metastasis	0.822 0.805 0.812	[101]
piR-5937	Colorectal cancer	down	TNM stage	0.806 0.718 0.725	[102]
piR-28876		down	TNM stage	0.8065 0.753 0.700	[102]
piR-54265		up	TNM stage, survival times and curative efficacy of chemotherapy	0.811 0.667 0.885	[45]
piR-823	Renal cell cancer	up	TNM stages	–	[103]
piR-823	Multiple myeloma	up	TNM stages	–	[60]
piR-651	classical Hodgkin lymphoma	down	the presence of lymphoma	–	[61]